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Is Tramadol a Dangerous Pain Reliever?

buy tramadol online. All the medicines have some degree of risk because they can cause mild to life-threatening side effects. When recommending a drug, healthcare professionals weigh the expected benefits and risks to determine whether it is worth taking. When you ask a doctor about a particular medication, they tell you about its positive and adverse effects and the warning that comes with the drug. Usually, newly approved medicines are the one that accumulates new warnings. However, sometimes, drugs available for a long time can also garner a new warning. Tramadol might become one such medicine to get a new warning due to increased death risk.

Tramadol Is Different From Other Medicines

Tramadol was not an opiate category drug when the FDA first approved it in 1995. Though it works similarly to other opiates like morphine or oxycodone, it was not in the same class. In 2014, the FDA put tramadol under the Controlled Substances Act as a schedule IV controlled substance due to abuse and addiction reports.

The controlled substance status means that though this medicine may have accepted medical use, the potential for addiction and abuse is high. Therefore the authorities strictly regulate its production and distribution. A person can only use a prescription for six months and get a maximum of five refills prescribed by the doctor.

When you compare it with other controlled substances, this drug is a safer option. Substances in schedule I like heroin have a high potential for abuse and addiction but no accepted medical use. In contrast, tramadol is a schedule IV substance, which means it has useful pain-relieving qualities and low potential for addiction and abuse.

Though there is a possibility of addiction and abuse, tramadol remains one of the most common treatments for painful conditions like osteoarthritis. Various professional institutions, including the American Academy of Orthopaedic Surgeons, recommend this medicine as a useful treatment against osteoarthritis.

What Research On Tramadol Suggest?

New research presented in the medical journal JAMA studied the death risk among about 90,000 people one year after their first Tramadol prescription or when they started using other commonly used pain-relievers. The study follows individuals over 50 years old having osteoarthritis.

The study found that people using tramadol were at a higher risk of death than those consuming anti-inflammatory medicines. For instance:

  • 2.2% of people using tramadol died compared to 1.3% of those using naproxen.
  • 3.5% of those using tramadol died compared to 1.8% of people using diclofenac.
  • 2.5% of people consuming tramadol died compared to only 1.2% of those consuming etoricoxib.

The researchers also found that people using codeine had a similar death risk to those using tramadol.

The study cannot conclusively prove whether tramadol treatment is responsible for the higher death rate or if the patients who took this medicine were at higher risk beforehand. People with comorbidity can make tramadol use risker than it is.

What Is Problematic About Tramadol Studies?

Researchers have not conducted the study in a controlled environment, which means it is prone to draw faulty conclusions for various reasons. Perhaps, the number of participants is not significant enough to find any meaningful difference. Maybe the dosage was too high or too low. Another significant error source in the study can be confounding.

It means an external or unexpected factor that the researchers were not examining caused the observed results. For example, suppose researchers compare two groups for heart attack risk, and the people in the higher risk group have a less healthy diet. They might believe that poor dietary choices lead to inferior heart health. But, what if the people with an unhealthy diet were also smoking more often than healthy eaters. In this case, smoking could be the reason for increased heart attacks. A researcher must account for the confounder (external factors) for the research to have credibility.

How Does Misleading Information Affect The Study Results?

With this study claiming that tramadol is more lethal than other pain relievers, confounding is a significant concern. For instance, people with kidney disease and arthritis might get a prescription for tramadol installed of naproxen because naproxen can worsen kidney disease. However, kidney problems could increase other health problems, including a higher death rate.

The researchers might attribute the problem caused by kidney disease to tramadol. Researchers conducting this study acknowledge the possibility of confounding and took measures to limit it, but it is impossible to account for unexpected factors accurately.


If you plan on taking tramadol, consult a doctor about its safety and talk to them about this study. Though the higher death rate among tramadol users is alarming, it is not clear that this medicine is the cause of the increased death risk.  We need more studies conducted to confirm or refute whether tramadol is responsible for the increased death rate.

If tramadol is the reason for increased death risk, we need to understand why and what we should do. Further research will also help doctors and patients to understand the potential risk of tramadol better.

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Is methadone effective for pain management?

Is methadone effective for pain management?

Methadone, also available as Methadose or Dolophine, is an opioid medication (sometimes narcotic). Methadone is a synthetic opioid agonist drug that helps opioid maintenance therapy during opioid dependence and chronic pain management. It is helpful as an analgesic in chronic pain, frequently in rotation with other opioids. One can achieve detoxification using Methadone within a month, or one can gradually get it done for as long as six months. This medicine is present in the market, and you can buy Methadone online from an excellent pharmaceutical website.

Methadone works on pain receptors in the body and reduces the pain you feel. It may replace other habit-forming opioid drugs. A single dose of this medication has a rapid effect; it can take five days of use to get the maximum impact. The pain-relieving effect lasts for six hours after a single Methadone dose. Order Methadone online from a count-on online pharmacy without hassle. Compare the rate at which the drug is available at different sites. Before buying the medication, check the shipping and delivery services.

When your doctor gives you Methadone under a treatment program for drug addiction or detoxification, the doctor may recommend taking the dose by a family member or other caregiver. Store Methadone away from heat and moisture at room temperature. Keep track of your drug. Be aware of misusing it or taking it without a prescription because Methadone is a drug of abuse. It is available in the market, but you can avail of it at discounted rates from our website. In terms of emergencies, buy Methadone overnight from our website-

Follow precisely your doctor’s prescription. Read carefully and follow all the prescription labels, medication guides, or instructions sheets. Never use Methadone in smaller or larger amounts than prescribed. If you are feeling an increased desire to use this medicine, then inform your doctor. Never share opioid prescriptions with someone else, especially someone with a past of drug abuse or addiction. Misuse of Methadone can cause addiction, overdose, or death. It is against the lawful act to sell or give away this opioid drug.

Do not suddenly stop taking this medicine. Before tapering the dose, talk to your doctor. For the treatment of opioid use disorder, doctors recommend using it as maintenance therapy or, in a short period, detoxification to manage opioid withdrawal symptoms. You can avail of it at a great deal because our website – is offering Methadone for sale.

Take Methadone (oral) by mouth. Injection of Methadone (injection) is under the skin or into a muscle or infused into the vein. Your healthcare provider will teach you to use this injection by yourself. Carefully measure liquid medicine. Use a dosing syringe or medicine dose-measuring device. On our website, you can readily buy liquid Methadone online. Dissolve the dispersible tablet in orange juice, water, or other citrus-flavoured (non-alcoholic) beverage. Never use Methadone liquid or tablets to make a mixture for injection into your vein. It may result in death with the use of prescription drugs.

Older adults, malnourished or debilitated, are more likely to have severe side effects. In addition, using opioid medicine for the longer term may affect the ability to have children (fertility) in men or women. However, it is still a question of whether opioid effects on fertility are temporary or permanent. Dispose of the leftover drug carefully. If someone is using this medicine improperly or accidentally, just one dose can cause death.

You should avoid using Methadone if you are allergic to it or have any blockage in your intestines or stomach, asthma (severe), or breathing problems. To ensure Methadone is safe for you, tell each of your healthcare providers if you ever had:

  • Sleep apnea, breathing problems;
  • Long QT syndrome (to any family member), heart problems;
  • Mental illness, or drug or alcohol addiction;
  • A brain tumour, head injury, or seizures;
  • Urination problems;
  • Kidney or liver disease;
  • Problems with your pancreas, gallbladder, or thyroid

Avoid breastfeeding because Methadone can pass into the breast milk and cause breathing problems, drowsiness, or death in a nursing baby. In addition, if you are using an opioid medicine during pregnancy, your baby could become drug-dependent. It can lead to life-threatening withdrawal symptoms in the newborn baby. An opioid-dependent baby may need treatment for several weeks.

Avoid alcohol consumption because it causes dangerous side effects, and death could occur. Interaction of grapefruit with Methadone can lead to unwanted side effects. Avoid using grapefruit products while taking this medicine. Opioid medication can stop or slow your breathing, and death may occur. An attendant should immediately go for medical attention if you have blue-coloured lips, slow breathing with long pauses, or if you are hard to wake up.

Avoid operating any machinery or driving vehicles until you know how this medicine will affect you. Dizziness or drowsiness (severe) can cause accidental falls or severe injuries.
The use of Methadone may cause nausea, constipation, vomiting, dizziness, lightheadedness, drowsiness, dry mouth, or sweating. Some of the side effects may be reduced after using this drug for a while. However, if any of them persists or worsens, tell your medical healthcare provider immediately.

A severe allergic reaction to Methadone is rare. However, take medical help if you notice any of the following symptoms: severe dizziness, rash, trouble breathing, itching, or swelling in your face, throat, lips, or tongue. To prevent constipation, drink enough water, eat dietary fibre, and exercise. Your doctor may also recommend you take laxatives. On our website- “,” you can buy Methadone without a prescription and choose the cash on delivery (COD) option for payment.

Usual adult dosage of Methadone:

For pain –

  • Initial dose- 2.5 to 10 mg IV every 8 to 12 hours
  • Maintenance dosage- gradually titrate to effect; may require frequent administration to maintain adequate analgesia while initiation; however, avoid overdosing with the help of extreme caution.

For chronic pain-

  • Initial dose- 2.5 mg every 8 to 12 hours orally
  • Maintenance dosage- gradually titrate to effect; may require frequent administration to maintain adequate analgesia while initiation; however, avoid overdosing with the help of extreme caution.

For opiate withdrawal-

  • Initial dose- 20 mg to 30 mg orally, an additional 5 to 10 mg orally after 2 to 4 hours if symptoms reappear or if withdrawal symptoms do not suppress
  • Maximum day one dose- 40 mg
  • Maximum initial dosage- 30 mg

Take urgent medical help if you have allergic reactions due to the use of Methadone. Signs of an allergic reaction include issues with breathing, hives, and swelling of your face, throat, lips, or tongue. In addition, seek medical help if you have serotonin syndrome symptoms, such as agitation, fever, hallucinations, sweating, fast heart rate, shivering, twitching, muscle stiffness, nausea, loss of coordination, vomiting, or diarrhoea.

Call your medical health care professional instantly if you have:

  • Severe constipation;
  • Breathing that stops during sleep, shallow or weak breathing;
  • Fluttering in your chest, fast or pounding heartbeats, shortness of breath;
  • Feeling lightheaded; or
  • Vomiting, nausea, dizziness, loss of appetite, worsening weakness or tiredness

Common side effects of Methadone include:

  • Nausea, vomiting;
  • Dizziness, drowsiness;
  • Increased sweating; or
  • Swelling, redness, or pain at the spot of injection
  • It is not a complete list of side effects, and others may occur. Take your doctor’s medical advice regarding side effects. In the USA, report side effects to FDA at 1-800-FDA-1088. And in Canada, report it to Health Canada toll-free at 1-866-337-7705.

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